ROLE OF SERUM ANTIMULLERIAN HORMONE FOR DIAGNOSIS OF POLYCYSTIC OVARIAN SYNDROME IN ADOLESCENCE

Abstract

Polycystic ovarian syndrome is one of the most common endocrinal pathology amongst reproductive age group females leading to various long term complications in future like infertility , cardiovascular diseases and diabetes mellitus in future. Thus, an early diagnosis and treatment may be helpful. Serum antimullerian hormone as is secreted by the primordial follicles will be raised in PCOS females even from adolescence after the development of HPO axis. Hence , it can be used as a diagnostic marker for PCOS in adolescence. Materials And Methods : It is a hospital based prospective case control study carried out in Gauhati Medical College and Hospital from April 2020 to March 2021. 110 adolescent girls between 15 years to 18 years were considered of which 55 fullled the inclusion criteria and 55 did not after which both the groups were subjected to a set of investigations including S. AMH. The comparison between two groups with qualitative data were done by chi square test and / or Fischer's test . associated risk factors were also determined. Results And Discussion: The serum AMH levels were considerably higher in cases of PCOS which was 11.83+ 3.62ng/ml compared to controls being 4.14 + 0.98 mg/ml (p<0.05) . Complaints of oligomenorrhoea with increase in BMI, signs of hirsutism and increase in LH and testosterone levels were found to be more common amongst the cases. Conclusion: In the study on Serum AMH level showed a statistically signicant rise in cases when compared to controls. It was noted that there was a rise in LH and total testosterone levels. So, it can be said that S.AMH does have a role for diagnosis of PCOS in adolescence.