Role of Salivary Biomarkers in Oral Cancer Detection- A Systematic Review

Abstract

Saliva is an informative biological fluid that has gained a lot of interest because of its physiologic diagnostic medium. The salivary secretions are under control of sympathetic and parasympathetic stimulation. It contains enzymes, proteins, biochemicals. It has been suggested to be ultrafiltrate of blood. The recent findings suggest that saliva could be used as a biomarker in diagnosing oral cancer. The study of saliva as a biological matrix has been identified as a new landmark initiative in search of a useful biomarker to diagnose oral cancer through and transcriptomes. Most oral cancers are oral squamous cell carcinoma using saliva for early oral cancer detection in the search for new clinical markers is a promising approach because of its noninvasive sampling and easy collection method. Identification of this salivary biomarker could help to screen patients at risk, predict disease outcome and effectively contribute to planning treatment strategies. Biomarkers in saliva can be used as for diagnostic & response to treatment in oral squamous cell carcinoma.in this review, we explored their application in this increasingly common disease. A systematic review of the literature was performed based on the English titles listed in the PubMed, EBSCO, Cochrane, Science Direct, ISI web Science, and SciELO databases using the keywords. This article may help to identify the potential biomarkers for screening and the molecular pathology analysis in the high-risk patients with the OSCC.