Role of Retinol Binding Protein -4(RBP-4) and some Biochemical Parameters in Type II Diabetes Mellitus Patients

Abstract

Diabetes is an important public health issue that adversely affects the lives of millions of individuals worldwide. RBP4 involvement in the pathogenesis of insulin resistance and type 2 diabetes. The aim of this study to assessment of role retinol binding protein -4 and other biochemical parameters in T2DM. Eighty eight participated in this study. Forty four T2DM, age between (40-60) years and forty four healthy control age between (40-55). there was a highly significant increase of FBS, HbA1C, TC, TG, LDL-C and VLDL-C, while a significant decreased of HDL-C between control and T2DM patients. There was a highly significant increase of RBP-4 level between different group (control and T2DM patients). Conclusion: Elevation of retinol in diabetic patients is considered a risk indicator for them with the early onset of cardiovascular disease, and this is a result of the continuous increase in the concentrations of sugar levels in the blood, and thus a defect in the metabolism of fats occurs, which leads to its rise, and this is an indicator of the entry of a diabetic patient with one of the complications, which is heart disease.