Abstract
Acute coronary syndrome (ACS) is the leading cause of mortality worldwide comprised with ST-segment elevation myocardial infarction (STEMI) and non ST segment elevation myocardial infarction (NSTEMI). A cross sectional study for a period from March 2015 to June 2016 was designed to find out the role of resistin in endothelium dysfunction in STEMI and NSTEMI patients and its correlation with cardiac markers troponins. 100 consented patients with diagnosed STEMI and NSTEMI with age range 40 to 70 years were included in the study. 50 age matched healthy subjects were taken as controls. Base line blood tests fasting blood sugar, blood urea, serum creatinine, serum total cholesterol and serum triglyceride were estimated by auto analyzer using standard kits. Special tests including serum resistin, cardiac troponin T and cardiac troponin I were estimated by the technique of ELISA. Results were analyzed by SPSS 20 and found that the base line parameters except serum creatinine were significantly raised in patients as compare to controls. Level of resistin and cardiac biomarkers cardiac troponin T (cTnT) and cardiac troponin I (cTnI) were significantly raised in STEMI patients as compared to NSTEMI patients. A significant positive correlation of resistin with cardiac troponin T and I was observed in STEMI patients only. It is therefore concluded that increased level of resistin along with cardiac markers may be presented as a predictor of injury of myocardium and in turn indicate the severity of AMI in STEMI patients.
Highlights
Acute coronary syndrome (ACS) is the leading cause of mortality worldwide, in the developing countries
non ST segment elevation myocardial infarction (NSTEMI) results from narrowing of coronary artery or micro-embolization of thrombus [1, 2]
A cross sectional study was designed to find out the role of resistin in endothelium dysfunction in segment elevation myocardial infarction (STEMI) and NSTEMI patients and its correlation with cardiac markers troponins
Summary
Acute coronary syndrome (ACS) is the leading cause of mortality worldwide, in the developing countries. NSTEMI results from narrowing of coronary artery or micro-embolization of thrombus [1, 2]. Resistin is a 12 Kda protein mainly secretes from macrophages and monocytes It may be a link between metabolic signals mediated inflammation and problem of atherosclerosis [3]. It is suggested that in atheromas resistin is secreted by International Journal of Clinical and Experimental Medical Sciences 2021; 7(5): 152-159 macrophages and promote inflammation of the vasculature. It promotes proliferation of smooth muscle cell and angiogenesis [4]. A link between increased level of resistin and coronary artery disease was observed and it is suggested that levels of resistin is found to be stepwise increase, depending on the number of segments or stenotic vessels [5, 6]
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