Abstract
Background Chronic obstructive pulmonary disease (COPD) is a gradually progressive disease, it might have a subordinate autoimmune pathogenesis. The CD4+CD25+FOXP3+T-regulatory cells (Treg) have an important role in controlling immune and allergic reactions. Objective To determine if Treg is involved in COPD and its value in the predilection of COPD development. Patients and methods This case–control study was conducted on 30 COPD patients and 20 age-matched and sex-matched healthy controls. Spirometry and flow cytometry were done. Results The Treg% was significantly lower in COPD than controls (P Conclusion Lower frequencies of Treg (autoimmunity) might be a risk factor for COPD development.
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