Abstract
Regulatory T cell (Treg) is a subset of T cell that actively suppresses autoimmunity,prevents immune injury and maintains immune homeostasis.It is characterized by continuous expression of CD25,specific expression of Foxp3 and low expression of CD127.It inhibits auto-reactive T cells through cell contact or secreting cytokines.Its immunosuppressive activity is regulated by many transcription factors,such as Foxp3,T-bet,interferon regulatory factor (IRF)-4,GATA-binding protein (GATA)-3 and signal transducers and activators of transcription (STAT)-3.In recent years,many researches found the frequency and number of Treg reducing in both animal models and clinical patients with IAA.In addition,some researches found that the function of Treg was deficient in IAA.Under the regulation of Foxp3,the suppression of Treg on autoreactive effector T cells was impaired which was considered as one of the pathogenesis of IAA.This review summarizes the general characteristics of Treg and the role of Treg in the pathogenesis of IAA. Key words: T-Lymphocytes,regulatory; Anemia,aplastic; Etiology
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