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Abstract
BackgroundThe study aimed to investigate the effects and reliability of simultaneous vertebroplasty and radiofrequency ablation or radiofrequency ablation applied alone for pain control in patients with painful spine metastasis, and to investigate the effect of preventing tumor spread in long-term follow-up.MethodsPatients with painful vertebrae metastasis in the Afyonkarahisar Health Sciences University, Medical Faculty, Hospital Neurosurgery Clinic between 01.01.2015 and 01.06.2020 were recruited. They were divided into groups according to the surgical procedures applied. Group 1 included 26 patients who underwent radiofrequency ablation only, and group 2 included 40 patients who underwent vertebroplasty with radiofrequency ablation. Computed tomography and magnetic resonance imaging were performed in all patients pre-operation. The patients were followed for at least 6 months. Magnetic resonance imaging was performed at the end of the 6th month in neurologically stable patients. The metastatic lesion, pain, and quality of life were evaluated with Visual Analog Scale and Oswestry Disability Survey before and after the procedure.ResultsThe mean VAS score before the procedure was 8.3 ± 1.07 in the RFA group, and a statistically significant difference was observed in VAS scores at all post-procedural measurement time-points (p < 0.001). The pain scores decreased at a rate of 58.8 and 69.6% of patients showed significant improvements in the QoL in the RFA-only group. The mean VAS score was 7.44 ± 1.06 in group RFA + VP before the procedure; the difference in the mean VAS scores was statistically significant at all measurement time-points after the procedure (p < 0.001). The mean pre-treatment Oswestry Index (to assess the QoL) was 78.50% in the RFA + VP group, which improved to 14.2% after treatment.ConclusionAblation + vertebroplasty performed to control palliative pain and prevent tumor spread in patients with painful vertebral metastasis is more successful than vertebroplasty performed alone.
Highlights
Spinal metastases are common in patients with advanced malignancies, with a reported prevalence of 30% [1]
This study evaluated the efficacy and reliability of simultaneous VP and radiofrequency ablation (RFA) for the palliative management of patients with metastatic vertebral metastases with consideration of the current knowledge on this subject
In group 2, none of the vertebrae treated during the 6-month follow-up period revealed tumour metastasis that could lead to advanced collapse and compression of the spinal cord
Summary
Spinal metastases are common in patients with advanced malignancies, with a reported prevalence of 30% [1]. The metastatic spread of tumours to the spine causes serious neurological problems arising from severe pain, spinal fractures, and compression of the nerve roots and spine by the lesion mass [7]. Ablation provides curative treatment for benign and malignant lesions measuring up to 3 cm. It reduces the tumour burden and mass effect on adjacent organs by reducing pain and effecting local disease control. This study evaluated the efficacy and reliability of simultaneous VP and RFA for the palliative management of patients with metastatic vertebral metastases with consideration of the current knowledge on this subject. The study aimed to investigate the effects and reliability of simultaneous vertebroplasty and radiofrequency ablation or radiofrequency ablation applied alone for pain control in patients with painful spine metastasis, and to investigate the effect of preventing tumor spread in long-term follow-up
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