Role of Quercetin as an effective Bioenhancer in Curcumin Absorption, In vitro Study

Abstract

Curcumin is a herbal drug obtained from the Curcuma longa which has good pharmacological activity in different biological system but it has low bioavilability as well as poor absorption rate and poor solubility in aqueous medium all these parameter can be corrected by using bioenhancers which enhance absorption and bioavailability of curcumin. Quercetin is a potential bioenhancer it has the ability to enhance the bioavilability of drugs by different methods in which some are proven like inhibition of Pgp efflux pump and metabolic enzymes and some of them still has question marks like as absorption enhancer and permeability enhancer. In this experiment our aim is to study bioenhancing property (as absorption enhancer) of Quercetin by enhancing the absorption of curcumin in intestinal lumen. Here chicken ileum was used to evaluate the bioenhancer property of Quercetin and for analysis UV spectroscopy was used for statistical analysis we used q- equation because here we used two different drugs and to maintain physiological condition tyroid salt solution was used, different concentration (200mg and 100mg in two different assemblies) of curcumin was used to compare the enhanced absorption of curcumin and only one assembly (which was 100mg curcumin)was installed with 50mg of quercetin . When curcumin is alone in the intestine its concentration is up to 1.098 mg in one hour and when quercetin combined with it then its concentration was 7.95 mg. the enhanced concentration of curcumin shows that quercetin is able to enhance the absorption as well as bioavilability of the curcumin.