Abstract

Nowadays Fluorescence Resonance Energy Transfer (FRET), which involves the nonradiative transfer of excitation energy from an excited state donor to a proximal ground-state acceptor, may be regarded as a useful tool in the design of ratiometric sensors. Recently, quantum dots (QDs), a kind of semiconductor nanoparticles, have been employed to modulate FRET. Compared with conventional FRET, quantum dot mediated FRET (QD-FRET) is advantageous because of their unique photophysical properties such as size tunable, narrow emission spectra but broad excitation spectra, strong signal intensity, high photostability, and good biocompatibility. Owing to these superior properties QDs have obtained huge development in many fields, such as drug testing, cell imaging, virus detection, molecular biology, medical diagnosis, electron transfer detection and so on. In view of above-mentioned achievements, QDs is a kind of promising material which can definitely be used as donors or acceptors in the FRET system. This review highlights the modern development of sensitive and selective ratiometric FRET based sensors where QDs has been used as fluorophores.

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