Abstract
Pyroptosis is a special way of programmed cell death which is dependent on the activation of cysteinyl aspartate specific proteinase 1 (Caspase-1) and Caspase-4/5/11. Ferroptosis is an iron-dependent cell death that characterized by the intra-cellular lipid peroxidation-mediated membrane damage. Pyroptosis or ferroptosis in macrophages, smooth muscle cells, and vascular endothelial cells are believed to be closely related to the progression of atherosclerotic plaques. Therefore, we discuss the role of pyroptosis and ferroptosis in the development of atherosclerotic plaques and may provide new strategies for the treatment of atherosclerosis.
Highlights
Atherosclerosis (AS) is caused by multiple risk factors including hypertension, diabetes, obesity, smoking and high blood cholesterol level
Pyroptosis is a unique form of cell death characterized by membrane perforation, cell swelling, membrane rupture and release of cell content
There is a growing number of evidences indicating that the activation of NLRP3 inflammasome is a key regulatory factor and maybe a biomarker of pyroptosis in the development of atherosclerotic plaques
Summary
Zhen Yang 1,2,3,4†, Junhe Shi 1,4,5†, Li Chen 1,2,3,4, Changgeng Fu 1*, Dazhuo Shi 1,2,3,4* and Hua Qu 1,4,5*. Cell Death and Survival, a section of the journal Frontiers in Cell and Developmental. Qu H (2022) Role of Pyroptosis and Ferroptosis in the Progression of Atherosclerotic Plaques. Pyroptosis is a special way of programmed cell death which is dependent on the activation of cysteinyl aspartate specific proteinase 1 (Caspase-1) and Caspase-4/5/11. Ferroptosis is an iron-dependent cell death that characterized by the intra-cellular lipid peroxidationmediated membrane damage. Pyroptosis or ferroptosis in macrophages, smooth muscle cells, and vascular endothelial cells are believed to be closely related to the progression of atherosclerotic plaques. We discuss the role of pyroptosis and ferroptosis in the development of atherosclerotic plaques and may provide new strategies for the treatment of atherosclerosis
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