Abstract
The role of pyridoxal phosphate and manganese ion in the iodination of tyrosine has been studied in vitro. Pyridoxal phosphate and manganous ion appear to generate an oxidant that is destroyed by catalase. In the presence of a specific thyroid iodide peroxidase these substances support iodination of tyrosine. Generation of an oxidant is also evident in the pyrogallol peroxidase assay but could not be demonstrated in assay of iodide peroxidation to triiodide. It is unlikely that pyridoxal phosphate and manganese chloride are components of the iodide peroxidase-tyrosine iodinase-iodotyrosine coupling system of the thyroid in vivo. (Endocrinology 88: 1263, 1968)
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