Abstract
pancreas the release into the duodenum of digestive enzymes dissolved in an alkaline, HC03 -rich fluid. The HC03 in the pancreatic fluid neutralizes the gastric acid content, which is important in preventing acid damage to the duodenal epithelium. Two main aspects of the role of HCO; and H+ transport in the pancreas have been studied. First. the role of HC03 in the secretion of fluid by the pancreatic ducts has been extensively studied. Many of these studies were carried out at the organ level, some of these were at the level of the isolated main duct. Only a few studies were performed on ductular cells because of their inaccessibility and the problems encountered in isolating ducts or ductu lar cells due to the small volume fraction of these cells in the pancreas (less than 4%). Second, a limited number of studies have been dedicated to the role of HC03 transport in the Ca2+ -dependent secretion of enzymes and fluid by the acinar cells. In this chapter we focus on the mechanism of H+ -HCO; transport and its relation to the transport of other ions by the ductular cells, and we briefly summarize the literature on the role of H+ and HCO; transport in the acinar cells.
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