Abstract

The cytokine tumor necrosis factor (TNF)-α is a key factor in the priming phase of liver regeneration since it activates the NF-κB signalling pathway, which primes hepatocyte for proliferation. In order to understand how TNFα-dependend NF-κB activation contributes to a cellular response in parenchymal liver cells, we aimed to generate a hepatocyte-specific mathematical model based on quantitative and time-resolved data of NF-κB pathway constituents after TNFα administration.

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