Role of protein A immunoadsorption in treatment of renal transplant recipients with HLA antibodies

Abstract

Objective To study the clinical effect of protein A immunoadsorption in renal transplant recipients with positive human leukocyte antigen (HLA) antibodies. Methods A total of 15 patients recieved renal transplantation in our hospital from 2013 to 2016 were enrolled in the study. Blood samples from 15 kidney transplant recipients before and after transplantation were collected and the HLA antibodies were detected by Luminex method. The relationship between protein A immunoadsorption and renal function was analyzed. Results IgG and HLA antibodies were significantly decreased in 11 renal transplant recipients after treated with protein A immunoadsorption, but there is no significant change in IgA and IgM. No acute or hyper-acute rejection occurred in 15 renal transplant recipients, and the renal function recovered to normal in 12 renal transplant recipients after protein A immunoadsorption. Conclusion Protein A immunoadsorption can effectively decrease the serum HLA antibodies and IgG level in renal transplant recipients, and can thus be used in prevention and treatment of rejection after renal transplantation. Key words: Kidney transplantation; Human leukocyte antigen antibody; Graft rejection; Protein A immunoadsorption