Abstract
Protease activated receptors are G –protein coupled receptors involved in hepatic fibrogenesis. PAR expressed on a number of cells including platelets, endothelial cells, monocytes, dendritic cells and hepatic stellate cells (HSC). They are activated after proteolytic cleavage by thrombin [1-3]. They augment the production of proinflammatory cytokines and profibrotic pathways. We herein review role of PAR in progression of liver disease.
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