Abstract
The role of prostaglandins (PGs) in spontaneous and oxytocin-induced uterine contractions was studied. Uterine segments from pregnant rats were monitored in vitro for isometric contractile activity in Krebs-Ringer medium (95% O2-5% CO2; 37 C). The medium was sampled periodically and assayed for PGE, PGF, and, in some cases, 13,14-dihydro-15-keto-PGF2a, by RIA. Uteri from 21-day pregnant rats demonstrated more PGE and PGF release and greater integrated contractile force (ICF) than uteri from 18-day pregnant rats. Upon analysis of the more active uteri of 21-day pregnant rats, a significant positive correlation was found between PG production and either ICF (P < 0.05) or contractile frequency (P < 0.001) but not with amplitude or duration of contractions. Oxytocin (20 mU) caused increased contractile activity in 18-day pregnant rat uteri, but no increase in PGE, PGF, or 13,14-dihydro-15-keto-PGF2a was observed. Indomethacin caused a decrease in PG proction as well as a reduction in contractile activity. Ind...
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