Abstract
Pancreatic cancer is expressed as a disorder of chaos that leads to impairment in biochemical and metabolic physiology of pancreas. It is considered as the most intractable and fatal among all gastrointestinal (GI) cancers. The early occurrence of metastatic spread and the development of intrinsic and acquired resistance during drug treatment limit its prognosis at the right time. The universalized treatment involves surgical resection in which only a minority (in vitro, animal and clinical studies are required for worthy manifestations.
Highlights
The human gut, the largest microbial reservoir in the body, harbors about 1013-14 microorganisms [1]
It was thought that can probiotics be a viable option for alleviating this infection? Recently, the supplementation of specific strains of probiotics like L. acidophilus, L. casei DN-114001, L. gasseri, and B. infantis was found successful for the eradication of H. pylori as compared with antibiotic therapy [147]
There is a wealth of research literature that clearly support a multifaceted role of probiotics in pancreatic cancer prevention by modulating pancreatitis and various other risk factors like diabetes, pancreatic necrosis, inflammation, obesity
Summary
The human gut, the largest microbial reservoir in the body, harbors about 1013-14 microorganisms [1] These microorganisms are collectively referred to as microbiota, while their collective genomes constitute known as the microbiome [2] [3]. Most of these gut microorganisms reside in the large intestine (colon), which contains an estimated 1011-12 bacterial concentrations per gram of content [4]. Commensal microorganisms in the gastrointestinal tract exert a significant effect on host biochemistry such as oxidation-reduction potential of luminal contents, enzymatic activity of intestinal contents, host physiology, short chain fatty acid production in the lumen, synthesis of vitamins and prevention against colonization by pathogen, immunomodulation and modification of host-synthesized molecules [6] [7]. Probiotic bacteria may be defined as “live microorganisms which when administered in adequate amounts confer a health benefit on the host” [12] and they most frequently belong to the lactic acid bacteria [LAB] category, such as Lactobacillus spp. and
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