Abstract
Stroke is the second most common cause of death globally and the leading cause of death in China. The pathogenesis of cerebral ischemia injury is complex, and oxidative stress plays an important role in the fundamental pathologic progression of cerebral damage in ischemic stroke. Previous studies have preliminarily confirmed that oxidative stress should be a potential therapeutic target and antioxidant as a treatment strategy for ischemic stroke. Emerging experimental studies have demonstrated that polyphenols exert the antioxidant potential to play the neuroprotection role after ischemic stroke. This comprehensive review summarizes antioxidant effects of some polyphenols, which have the most inhibition effects on reactive oxygen species generation and oxidative stress after ischemic stroke.
Highlights
Stroke is the second most common cause of death globally and the leading cause of death in China [1, 2]
An emerging study has found that irisin was an independent prognostic marker of ischemic stroke patients, whose decreased concentration is associated with poor outcome of patients [7]
A comparative study demonstrated that pretreated with polymeric N-isopropylacrylamide (PNIPAM) nanoformulation of curcumin, demethoxycurcumin, and bisdemethoxycurcumin intranasal delivery significantly improved neurological deficits, locomotor activity, and grip strength by decreasing the level of lipid peroxidation (LPO) and increasing the activities of antioxidant enzymes (GSH-Px, glutathione reductase, superoxide dismutase (SOD), and CAT) in middle cerebral artery occlusion (MCAO) rats
Summary
Stroke is the second most common cause of death globally and the leading cause of death in China [1, 2]. Ischemic stroke had a high incidence and mortality rate [5, 6], which seriously affects patient life quality and brings heavy mental and economic burden to the family of patients Both diagnosis and treatment of stroke present enormous challenges. Emerging experimental studies have demonstrated that polyphenols exert the antioxidant potential to play the neuroprotection role after ischemic stroke [20]. This comprehensive review summarizes antioxidant effects of some polyphenols, such as flavonoids, phenolic acids, curcuminoids, stilbenoids, and lignans, which have the most inhibition effects on ROS generation and oxidative stress after ischemic stroke
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