Abstract
Prostate cancer (PCa) affects 161,360 people in the USA in 2017 and is responsible for nearly 26,730 deaths, accounting for 19% of all new cases and 8% of all cancer deaths in men (1). Previous studies suggested that prostate-specific antigen (PSA)-screening could reduce PCa mortality by 27% (2). However, screening could also bring over-diagnosis, subsequent over-treatment and a higher disease burden.
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