Abstract
Introduction: Venous ulcers are wounds that are thought to occur due to improper functioning of venous valves, usually of the lower limbs. Considering that PRP is a source of growth factors, and consequently has mitogenic, angiogenic, and chemotactic properties, it represents an adjunctive treatment for recalcitrant wounds. Moreover, PRP provides the wound with adhesive proteins, such as fibrinogen, which are important in wound healing. PRP contain more amount of platelets, cytokines and growth factors which are dispersed in a very small amount of plasma which can be prepared from a sample of centrifuged autologous blood. Application of PRP has been reported to be effective in both acute as well as chronic non healing venous ulcers. 
 Aim and Objective: To evaluate the efficacy of autologous platelet rich plasma in the management of chronic venous ulcer. Material and Method: A Prospective study conducted on 100 patients of chronic venous ulcers admitted in Sir T. Hospital Bhavnagar from June 2018 to June 2019 after fulfilled our inclusion and exclusion criteria. PRP then injected intalesionally inside and around the periphery of the wound/ulcer. This process was done once/week for 12 weeks. At every week, the area and volume of ulcer was calculated and photographs were taken. 
 Result: All the patients showed healing of the ulcer with reduction in size of ulcer more than 90% was observed in 72 patients, followed by 80–90% reduction in wound size in 18 patients after the 12 weeks follow-up. Overall, significant reduction in size of ulcer was observed in all the treated patients.
 Conclusion: Autologous platelet rich plasma (PRP) as an autologous method, it is biocompatible, simple, safe, affordable and less expensive procedure in the treatment of chronic venous ulcers. PRP is found to be useful in improving and enhancing the healing process in chronic venous leg ulcers without any side effect.
 Keywords: Venous ulcer, Platelet rich plasma
Highlights
Introduction: Venous ulcers are wounds that are thought to occur due to improper functioning of venous valves, usually of the lower limbs
Considering that platelet rich plasma (PRP) is a source of growth factors, and has mitogenic, angiogenic, and chemotactic properties, it represents an adjunctive treatment for recalcitrant wounds
To date, no robust scientific evidence exists to conclude that any dressing is superior to others, and conventional wound care does not supply the growth factors essential to the wound healing process,[4] which have been proven to be present in platelets
Summary
Venous ulcers are wounds that are thought to occur due to improper functioning of venous valves, usually of the lower limbs. Conclusion: Autologous platelet rich plasma (PRP) as an autologous method, it is biocompatible, simple, safe, affordable and less expensive procedure in the treatment of chronic venous ulcers. Platelets are anucleate fragments of megakaryocytes that originate in the bone marrow and travel in the bloodstream for 7–10 days These cellular elements contain a wide protein content in their secretory granules (dense granules, lysosomes, and mainly α-granules).During the physiological process of wound heling, platelets are activated at the site of injury with release of growth factors and cytokines over time during fibrin retraction. Autologous platelet rich plasma (PRP) is a safe, simple, affordable and less expensive procedure in the treatment of chronic ulcers with reportedly good results. It is an autologous method, it is biocompatible and safe.[13]Aim of study is to evaluate the efficacy of autologous platelet rich plasma in the management of chronic venous ulcer
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