Abstract
PurposeRetinal vein occlusion (RVO) and diabetic retinopathy (DR) are two major sight-threatening diseases which may lead to neovascular glaucoma (NVG). The aim of this study was to explore the association between platelet parameters and NVG.MethodsA total of 185 subjects were enrolled for the study from January, 2012 to December, 2015 at the Eye-ENT Hospital of Fudan University. Patients include those with NVG secondary to RVO (RVO group, n = 38), patients with NVG secondary to DR (DR group, n = 47), diabetics mellitus without retinopathy (DM group, n = 52), and healthy individuals (control group, n = 48). A complete ophthalmological examination including visual field examination, A-scan ultrasound, Fundus photography, and measurement of platelet parameters were performed for NVG subjects.ResultsThere was no statistical difference in the mean age and gender among the RVO, DR, and control groups (p>0.05). The mean level of platelet distribution width (PDW) was higher (p<0.001) in the RVO group (15.16±2.13fl) and DR group (16.17±1.66fl) when compared with the control group (13.77±2.99fl). The mean plateletcrit (PCT) value of the RVO group (0.229±0.063%) was also higher (p = 0.049) than the control group (0.199±0.045). In the DR group, mean platelet volume (MPV) value (10.72±1.57fl) was significantly higher (p = 0.002) than the control group (9.75±0.89fl). A similar trend was observed when platelet parameters were compared among the 3 groups with respect to age. The mean level of PDW was significantly higher (p<0.001) in the DR group (16.17±1.66fl) compared with the DM group (13.80±3.32fl). Stepwise multiple logistic regression analysis revealed that PDW (OR = 1.44, 95%CI = 1.149–1.805, p = 0.002) and MPV (OR = 1.503, 95%CI = 1.031–2.192, p = 0.034) were associated with the DR group, PDW (OR = 1.207, 95%CI = 1.010–1.443, p = 0.039) and PCT (OR = 1.663, 95%CI = 1.870–2.654, p = 0.036) were associated with the RVO group.ConclusionOur results suggest that increased PDW and MPV are associated with the NVG secondary to DR group, elevated PDW and PCT are associated with the RVO group. It indicates that platelets might be an important factor in the onset and/or development of NVG.
Highlights
Neovascular glaucoma (NVG) is a frequent complication associated with ischaemic retinopathies such as retinal vein occlusion (RVO) and diabetic retinopathy (DR)
Our results suggest that increased platelet distribution width (PDW) and Mean platelet volume (MPV) are associated with the NVG secondary to DR group, elevated PDW and PCT are associated with the RVO group
Stepwise multiple logistic regression analysis revealed that PDW (OR = 1.44, 95%CI = 1.149– 1.805, p = 0.002) and MPV (OR = 1.503, 95%CI = 1.031–2.192, p = 0.034) were associated with DR after adjusting for age, sex, PLT, PDW, PCT, MPV, and hypertension (Table 6)
Summary
Neovascular glaucoma (NVG) is a frequent complication associated with ischaemic retinopathies such as retinal vein occlusion (RVO) and diabetic retinopathy (DR). Mean platelet volume (MPV) is a major indicator of the production rate and size of platelets, and has been associated with the activities of platelets [9, 10]. Yazgan S et al [17] suggested that the PCT and PDW were significantly higher in patients with PEX syndrome than in controls. Sahin A et al [8] reported that patients with RVO had significantly higher MPV values compared with the control subjects. Aksoy Y et al [18] suggested that MPV values were significantly higher in branch RVO patients compared with the control subjects. Inconsistent results showing that the MPV was significantly lower in patients with RVO than a control group were reported by Ornek N et al [19]. To our knowledge, we did not find any articles that assessed platelet parameters in patients with NVG secondary to DR and RVO
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