Role of plasma immunoglobulin receptor (PIgR/SC) in diagnosis of liver cancer

Abstract

Objective To investigate the diagnostic value of PIgR/SC in diagnosis of primary hepatic cancer. Methods 58 patients with primary hepatic cancer, 60 patients with liver cirrhosis and 60 healthy volunteers were studied.4 ml fasting venous blood was collected from all subjects. Serum level of AFP was detected with electrochemical chemiluminescence immunoassay system and plasma PIgR/SC level was detected by ELISA method. The level of PIgR/SC and AFP was detected at one week after surgical resection in patients with hepatic cancer. Results The levels of AFP and PIgR/SC in the three groups were significantly different (P 0.05) . AFP was higher in patients with HCC than patients with cirrhosis and volunteers. AFP was higher in patients with cirrhosis than volunteers, and the difference was statistically significant (P<0.01) . Sensitivity of PIgR/SC and AFP was 89.3% and 54.8%, specificity was 84.6% and 91%, Youden index was 0.751 and 0.458, AUC was 0.920 and 0.761, respectively. There was significant difference in AUC (Z=3.251, P<0.05) of the two detection indexes for detection of primary hepatic cancer. Conclusion The value of PIgR/SC in diagnosis of primary liver cancer may by higher than that of AFP. Key words: Polymeric immunoglobulin receptor/secretory component; Primary liver cancer; Alpha fetal protein