Abstract
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that is mainly mediated by pathological T-cells. Experimental autoimmune encephalomyelitis (EAE) is a well-known animal model of MS that is used to study the underlying mechanism and offers a theoretical basis for developing a novel therapy for MS. Good therapeutic effects have been observed after the administration of natural compounds and their derivatives as treatments for EAE. However, there has been a severe lag in the research and development of drug mechanisms related to MS. This review examines natural products that have the potential to effectively treat MS. The relevant data were consulted in order to elucidate the regulated mechanisms acting upon EAE by the flavonoids, glycosides, and triterpenoids derived from natural products. In addition, novel technologies such as network pharmacology, molecular docking, and high-throughput screening have been gradually applied in natural product development. The information provided herein can help improve targeting and timeliness for determining the specific mechanisms involved in natural medicine treatment and lay a foundation for further study.
Highlights
Multiple sclerosis (MS) is an autoimmune disease that occurs in the central nervous system (CNS) (Alroughani et al, 2020)
A study was performed that used network pharmacology to research the molecular mechanisms of Lian Hua Qing Wen in novel coronavirus disease, and the results showed that its mechanisms are closely related to modulating inflammation, antiviral action, and protecting the lungs (Zheng et al, 2020)
In the EAE model, most of these Chinese herbal monomers can inhibit the production of inflammatory factors such as IL-1β and IL-17; promote antiinflammatory factors such as IL-10, transforming growth factor (TGF)-β, and others; and regulate pro-inflammatory and anti-inflammatory balance
Summary
Multiple sclerosis (MS) is an autoimmune disease that occurs in the central nervous system (CNS) (Alroughani et al, 2020). There have been many studies of the treatment of EAE by TCM monomers containing flavonoids, phenol, and glycosides, among others (Ciumarnean et al, 2020; Ikram et al, 2020; Yang L. et al, 2020). Over the past 8 years, glycosides have been the most commonly studied compounds, and have been examined and developed with the intent of using them as a potential treatment for EAE (Giacoppo et al, 2013; Yin et al, 2014; Haghmorad et al, 2017; Madhu et al, 2019; Yang L. et al, 2020). Therapeutic studies of EAE mainly concentrate on identifying traditional TCM monomers that have the ability to protect BBB integrity and possess anti-inflammatory or neuroprotective properties.
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