ROLE OF PHOTOBIOMODULATION OF MAJOR SALIVARY GLANDS IN PATIENTS WITH CHRONIC RENAL FAILURE IN THE SALIVARY FLOW RATE

Abstract

Objective To evaluate the effects of low-level laser photobiomodulation on the major salivary glands in patients with chronic renal failure. Study Design After the ethics board approved the protocol, 38 patients with chronic renal failure (CRF) on hemodialysis were enrolled into this prospective study (21 included in the study group and 17 in the control group, randomly). All patients were submitted to oral clinical examination anamnesis and physical examination. Stimulated and nonstimulated salivary flow rate were collected before and after photobiomodulation with low-level laser application. Laser application comprised 3 points extraorally and intraorally in each parotid gland, 1 point in each submandibular, and 1 point in the sublingual glands. Salivary flow rate was collected before photobiomodulation and after 3 applications (weekly). Results Nonstimulated salivary flow rate in study group was 3.06 mL/min and 3.83 mL/min (P = .02) before and after photobiomodulation, while stimulated salivary flow rate in study group was 3.5 mL/min and 4.4 mL/min (P = .01) before and after photobiomodulation. Comparison between placebo group and study group did not show differences. Conclusion Low-level laser photobiomodulation of the major salivary glands increased around 25% of salivary flow rate in CRF patients. To evaluate the effects of low-level laser photobiomodulation on the major salivary glands in patients with chronic renal failure. After the ethics board approved the protocol, 38 patients with chronic renal failure (CRF) on hemodialysis were enrolled into this prospective study (21 included in the study group and 17 in the control group, randomly). All patients were submitted to oral clinical examination anamnesis and physical examination. Stimulated and nonstimulated salivary flow rate were collected before and after photobiomodulation with low-level laser application. Laser application comprised 3 points extraorally and intraorally in each parotid gland, 1 point in each submandibular, and 1 point in the sublingual glands. Salivary flow rate was collected before photobiomodulation and after 3 applications (weekly). Nonstimulated salivary flow rate in study group was 3.06 mL/min and 3.83 mL/min (P = .02) before and after photobiomodulation, while stimulated salivary flow rate in study group was 3.5 mL/min and 4.4 mL/min (P = .01) before and after photobiomodulation. Comparison between placebo group and study group did not show differences. Low-level laser photobiomodulation of the major salivary glands increased around 25% of salivary flow rate in CRF patients.