Role of phosphorylated delta sleep inducing peptide (p-DSIP) on sleep architecture and spatial memory impairment of rats under chronic hypobaric hypoxia

Abstract

Event Abstract Back to Event Role of phosphorylated delta sleep inducing peptide (p-DSIP) on sleep architecture and spatial memory impairment of rats under chronic hypobaric hypoxia Koustav Roy1, Krishna Kishore1*, Koushik Ray1, Meetu Wadhwa1, Vishal Jain1, Garima Chauhan1, Punita Kumari1, Shahnawaz Alam1, Usha Panjwani1 and Shashi Bala Singh1 1 Defence Institute of Physiology and Allied Sciences (DIPAS), Defence Research and Development Organization (DRDO), Neurophysiology, India Sleep architecture alteration is one of the causes for sleep deprivation at high altitude. Hypobaric hypoxia (HH) affects non rapid eye movement sleep (NREM) followed by alteration in rapid eye movement sleep. NREM plays major role in spatial memory. Delta sleep inducing peptide (DSIP) is a well known peptide playing a role in improving sleep quality. Previous studies have shown HH induced memory impairments but its correlation with sleep deprivation is still need to be understood. The present study was designed to evaluate the role of sleep in HH induced cognitive declined. Animals were exposed to HH stress at 25,000 feet for continuous 7 days. P-DSIP was given as intervention at a dose of 10µg/kg/day for positive control. Norepinephrine (NE), serotonin and dopamine (DA) levels were measured from hippocampus, cortex, brain stem and hypothalamus by HPLC. Result showed that concentration of NE and DA were more increased after chronic hypoxia than control group. The finding may be due to over activity of tyrosine hydroxylase. Serotonin level was decreased in hypoxia group. It may be casued by the less activity of tryptophan hydroxylase as it is more sensitive to oxygen than monoamine oxidase (MAO). On the other hand, in p-DSIP treated group NE and DA levels significantly decrease than without drug treated group and serotonin level was significantly increases. Morris water maze (MWM) performance was significantly improved in p-DSIP treated hypoxic rats than only hypoxia group. MWM performance improvement may be due to improvement of serotonin level in drug treated group. P-DSIP has a major possibility to improve quality of sleep in drug treated group, which may directly play a positive role in MWM performance. Keywords: Memory, Sleep, neurotransmitters, in vivo, hypobaric hypoxia Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: Poster Presentation Session Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Roy K, Kishore K, Ray K, Wadhwa M, Jain V, Chauhan G, Kumari P, Alam S, Panjwani U and Singh S (2016). Role of phosphorylated delta sleep inducing peptide (p-DSIP) on sleep architecture and spatial memory impairment of rats under chronic hypobaric hypoxia. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00138 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Aug 2016; Published Online: 11 Aug 2016. * Correspondence: Dr. Krishna Kishore, Defence Institute of Physiology and Allied Sciences (DIPAS), Defence Research and Development Organization (DRDO), Neurophysiology, Delhi, Delhi, India, kishu16in@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Koustav Roy Krishna Kishore Koushik Ray Meetu Wadhwa Vishal Jain Garima Chauhan Punita Kumari Shahnawaz Alam Usha Panjwani Shashi Bala Singh Google Koustav Roy Krishna Kishore Koushik Ray Meetu Wadhwa Vishal Jain Garima Chauhan Punita Kumari Shahnawaz Alam Usha Panjwani Shashi Bala Singh Google Scholar Koustav Roy Krishna Kishore Koushik Ray Meetu Wadhwa Vishal Jain Garima Chauhan Punita Kumari Shahnawaz Alam Usha Panjwani Shashi Bala Singh PubMed Koustav Roy Krishna Kishore Koushik Ray Meetu Wadhwa Vishal Jain Garima Chauhan Punita Kumari Shahnawaz Alam Usha Panjwani Shashi Bala Singh Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.