Role of PhOH and Tyrosine in Selective Oxidation of Hydrocarbons

Ludmila Matienko,Elena Mil,Vladimir Binyukov,Alexander Goloshchapov

doi:10.3390/catal11091032

Abstract

Earlier, we established that nickel or iron heteroligand complexes, which include PhOH (nickel complexes) or tyrosine residue (nickel or iron complexes), are not only hydrocarbon oxidation catalysts (in the case of PhOH), but also simulate the active centers of enzymes (PhOH, tyrosine). The AFM method established the self-organization of nickel or iron heteroligand complexes, which included tyrosine residue or PhOH, into supramolecular structures on a modified silicon surface. Supramolecular structures were formed as a result of H-bonds and other non-covalent intermolecular interactions and, to a certain extent, reflected the structures involved in the mechanisms of reactions of homogeneous and enzymatic catalysis. Using the AFM method, we obtained evidence at the model level in favor of the involvement of the tyrosine fragment as one of the possible regulatory factors in the functioning of Ni(Fe)ARD dioxygenases or monooxygenases of the family of cytochrome P450. The principles of actions of these oxygenases were used to create highly efficient catalytic systems for the oxidation of hydrocarbons.

Highlights

Earlier, we established that nickel or iron heteroligand complexes, which include PhOH or tyrosine residue, are hydrocarbon oxidation catalysts, and simulate the active centers of enzymes (PhOH, tyrosine)
We present for the first time the atomic force microscopy (AFM) image of supramolecular structures based on {Hem+PhOH+His} complexes, as well as the design of the structures of {Hem+Tyr+His} complexes based on the obtained AFM data
Using atomic force microscopy (AFM), we showed for the first time the self-organization supramolecular complexes

Summary

Introduction

We established that nickel or iron heteroligand complexes, which include PhOH (nickel complexes) or tyrosine residue (nickel or iron complexes), are hydrocarbon oxidation catalysts (in the case of PhOH), and simulate the active centers of enzymes (PhOH, tyrosine). The AFM method established the self-organization of nickel or iron heteroligand complexes, which included tyrosine residue or PhOH, into supramolecular structures on a modified silicon surface. Using the AFM method, we obtained evidence at the model level in favor of the involvement of the tyrosine fragment as one of the possible regulatory factors in the functioning of Ni(Fe)ARD dioxygenases or monooxygenases of the family of cytochrome P450. The development of industrial processes for the oxidation of hydrocarbons is determined by the ability of researchers to control these processes. An effective method of controlling the rate and mechanism of hydrocarbon oxidation is the use of a catalyst

Methods

Results

Discussion

Conclusion