Abstract
A peptide-containing fraction was extracted from the ventral parts of the rat mesencephalon; donor animals had been subjected to kindling by repeated picrotoxin injections (1.0–1.2 mg/kg). Intraventricular administration of the extract (20 µg in 10 µl isotonic NaCl solution per animal) increased the manifestation of picrotoxin-induced (2.0 mg/kg) convulsions in the intact recipient rats; at the same time, injection of a hippocampal extract in the same doses did not produce such an effect. Proepileptic effects of the injected extract from the ventral mesencephalic region (VMR) tissue were removed by naloxone (1.0 mg/kg) injection. A decrease of β-endorphin, met-enkephalin, and δ-sleep-inducing peptide content in the VMR tissue and the hippocampus has been found in kindling-subjected animals.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
