Abstract
The purpose of the study was to analyze and summarize data regarding a significance of PD -L1 expression in various molecular subtypes of colorectal cancer.Material and Methods. A systemic literature search was conducted in the electronic databases Medline, Cochrane Library, Elibrary, PubMed. Of identified and reviewed 201 full-text articles, we included data from 47 studies.Results. The literature review described the features of the molecular genetic classification of colorectal cancer and revealed the key characteristics of each of the molecular subtypes of this disease. Much attention was paid to the molecular mechanisms of anti-PD -1/PD -L1 therapy. The main problems associated with the standardization of methods for pathomorphological assessment of the expression of this marker and the difficulties of its interpretation in colorectal carcinomas were outlined.Conclusion. Analysis of the literature revealed problems associated with the assessment of PD -L1 expression in colorectal cancer, in particular, with the lack of generally accepted methods for interpreting research results and standardizing methods for pathomorphological diagnosis of malignant tumors of this localization. Further studies are needed for introducing the molecular genetic classification of colorectal carcinomas into a wide clinical practice and personalizing the approach to therapy of this disease.
Highlights
В настоящее время широкое применение в клинической практике получил метод иммунотерапии злокачественных новообразований (ЗНО) с применением ингибиторов контрольных
The purpose of the study was to analyze and summarize data regarding a significance of PD-L1 expression in various molecular subtypes of colorectal cancer
The literature review described the features of the molecular genetic classification of colorectal cancer and revealed the key characteristics of each of the molecular subtypes of this disease
Summary
Для цитирования: Вторушин С.В., Наумов C.C., Степанов И.В., Синянский Л.Е., Афанасьев С.Г. РОЛЬ ОЦЕНКИ PD-L1 В АСПЕКТЕ МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКОЙ КЛАССИФИКАЦИИ КОЛОРЕКТАЛЬНОГО РАКА. Описываются особенности молекулярно-генетической классификации колоректального рака, даются ключевые характеристики каждого из молекулярных субтипов карцином этой локализации. Значительное внимание уделено молекулярным механизмам анти- PD-1/PD-L1-терапии, обозначены основные проблемы, связанные со стандартизацией методов патоморфологической оценки экспрессии этого маркера и с трудностями ее интерпретации и учета при колоректальных карциномах. Анализ литературы выявил ряд проблем, связанных с оценкой PD-L1 экспрессии при колоректальном раке, в частности отсутствие общепризнанных методик интерпретации результатов исследования и стандартизации методов патоморфологической диагностики злокачественных опухолей этой локализации. ROLE OF PD-L1 ASSESSMENT IN THE ASPECT OF MOLECULAR-GENETIC CLASSIFICATION OF COLORECTAL.
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