Role of PD-1 and immune cells in HSV infection and latency.

Abstract

A large proportion of the world's population is infected with HSV-1. Antiviral CD8+ T cells and CD8α+ dendritic cells are closely related to HSV-1 infection and latency. Latency-associated transcript of HSV-1 and PD-1are involved in the regulation of latency and reactivation of HSV-1. Here, the role of latency-associated transcript, PD-1, CD8+ T cellsand CD8α+ dendritic cells in HSV-1 infection, the inter-relationships betweenthemand how these interactions leadto latency are discussed, possibly providing new ideas for the treatment of HSV-1 infection.