Role of Pcsk9 In The Diagnosis Thyroid Disorder in Patient Women

Hassanein Fadel Mohammed,Sarah Hassan Jaber

doi:10.46966/msjar.v2i1.16

Hassanein Fadel Mohammed, Sarah Hassan Jaber

Open Access

https://doi.org/10.46966/msjar.v2i1.16

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Abstract

This study for the diagnosis of thyroid using pcsk9.The current study was conducted on seventy women patients suffering from thyroid disease attending in Center for diabetes and Endocrinology Unit in each of Al-Sadder Teaching Hospital and AL FURAT AL AWSAT Hospital in Al-Najaf province/ Iraq, and during the period from September until December 2017. The sample patients were divided into four study groups: premenopausal hypothyroidism patients group (20), postmenopausal hypothyroidism (15), premenopausal hyperthyroidism patients groups (17), and postmenopausal hyperthyroidism (18). The control group composed of 18 healthy women, also divided into premenopausal control and postmenopausal control. The results indicated a significant increase (p<0.05) in pcsk9 in hypothyroidism patients compared with the control group, while a significant decrease (p<0.05) in pcsk9 in hyperthyroidism patients compared with the control group. The results indicated a significant decrease (p<0.05) in pcsk9 in premenopausal hyperthyroidism patients compared with the control group, and a significant decrease (p<0.05) in pcsk9 in postmenopausal hyperthyroidism patients compared with the control group. The results indicated a significant increase (p<0.05) in pcsk9 in premenopausal hypothyroidism patients compared with the control group, and a significant increase (p<0.05) in pcsk9 in the postmenopausal hypothyroidism patients compared with the control group, also a significant increase in pcsk9 in postmenopausal than premenopausal.

Highlights

Thyroid gland is one of the biggest endocrine glands in the human body, it lies in neck under larynx and anterior to trachea
It secretes two types of hormones Triiodothyronine (T3) and Thyroxine (T4) which are responsible of regulating metabolic processes in body, any defect either in hypo- or hyperthyroidism leads to many problems associated with metabolism (Guyton and Hall, 2016).Hyperthyroidism, which means thyroid gland, is over active and produces additional hormone than normal, this occurs due to several causes such as immunologic state and thyroid tumor (Barrett et al, 2016)
The current study revealed significant differences in pcsk9 between hypo and hyperthyroidism compared with control, significantly increased (p

Summary

INTRODUCTION

Thyroid gland is one of the biggest endocrine glands in the human body, it lies in neck under larynx and anterior to trachea It secretes two types of hormones Triiodothyronine (T3) and Thyroxine (T4) which are responsible of regulating metabolic processes in body, any defect either in hypo- or hyperthyroidism leads to many problems associated with metabolism (Guyton and Hall, 2016).Hyperthyroidism, which means thyroid gland, is over active and produces additional hormone than normal, this occurs due to several causes such as immunologic state and thyroid tumor (Barrett et al, 2016). The hypothyroidism classified into primary and secondary hypothyroidism, if permanent loss or damage of the thyroid, through processes such as autoimmune damage or irradiation injury, was described as primary hypothyroidism (Caturegli et al, 2014), whereas if deficient stimulation of the normal gland, as a result hypothalamic or pituitary disease or defects in the TSH molecule or cause outside gland itself, it is called central or secondary hypothyroidism ( Persani , 2012). The plasma PCSK9 concentration is higher in female compared to male and the PCSK9 concentrations decrease with age in males, but increase in females (Baass et al, 2009, Lakoski et al, 2009)

Findings

DISCUSSION

CONCLUSION