Abstract
The role of particle size in experimental respiratory tumor formation was studied by intratracheal instillation of two different particle sizes of benzo(a)pyrene into Syrian golden hamsters. One group of hamsters received large particles ( 64% above 10 μ m), the second group was treated with smaller-sized particles ( 98% less than 10 μ m). Otherwise, treatment was similar. Only 5 respiratory tumor-bearing animals of 48 were found in the group receiving small particles, whereas 31 respiratory tumor-bearing animals of 48 were found in the group which received the larger particles. Analysis of the retention rate of instilled B(a)P showed that small particles cleared much more rapidly from the lungs than did the larger particles.
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