Abstract
We read with great interest the article by Nishio et al. that emphasizes the role of paraoxonase-1 in Japanese patients with cytochrome P450 (CYP) 2C19 loss-of-function (LOF) phenotype [1]. Based on results in 112 patients, the authors found that low PON1 activity was associated with low response to clopidogrel only in LOF carriers. In addition to the limited statistical power, another major limitation concerns the lack of correlation between PON1 activity and response to clopidogrel in LOF carriers in the tertiles 2 and 3.
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