Abstract
Pap-smear-based cytology is used widely in detecting cervical precancerous lesions and still needs further standardization. Co-expression of p16 can be used as an additional biomarker for detection of cervical lesions. The aim of the study was to assess the diagnostic value of Pap smears and detection of the p16 proteins in women with cervical lesions. Totally 66 cases of cervical smear were taken, out of whom 14 samples were cytologically normal, 16 samples were inflammatory, 15 samples had low squamous intraepithelial lesions (LSIL), 11 samples had high squamous intraepithelial lesions (HSIL) and 10 samples had cervical squamous cell carcinoma (SCC). The expression of p16 was evaluated by immunohistochemical method. The immunostaining results of p16 were classified into four categories: negative, 1+, 2+ and 3+. There was a significant increase in the expression of p16 (P < 0.001) from cytologically normal to SCC. The expression of p16 (P = 0.01) was significantly increased in inflammatory, LSIL, HSIL and squamous cell carcinoma, and the results were compared with those of Pap smear cytology. The result of p16 was compared with that of Pap smear cytology and can improve the diagnostic accuracy of cervical lesions. p16 expressions increase from inflammatory to LSIL, HSIL and SCC.
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