Abstract

Objectives To investigate the correlation between bone metastases in patients with prostate cancer and P504S expression,Gleason score.Methods From July 2012 to June 2013,58 patients with prostate cancer were collected in our hospital,in which 32 with bone metastasis and 26 without bone metastasis.P504S expression in tissue of prostate cancer were measured using immunohistochemical two-steping of EnVision,All of patients underwent whole body radionuclide bone scan.The role of P504S and Gleason score in bone metastasis were analyzed.Results For prostate cancer with bone metastasis,P504S expression was strength,correlation coefficients were 0.818,there are statistically significant differences (P ＜0.05) ; correlation coefficient with the Gleason scores was 0.474,P ＜ 0.007.By rank and inspection analysis in groups and no bone metastases of bone metastases,P504S expression difference was statistically significant (Z =4.110,P ＜ 0.001),the rank and inspection analysis of bone metastases group and no group of bone metastases of Gleason score,difference was statistically significant (Z =3.372,P =3.372).Conclusions High expression of P504S in prostate cancer patients might be used as a biomarker for bone metastasis in patient with prostate cancer as well as a sensitive indicator of prognosis. Key words: Prostatic Neoplasms; Neoplasm Metastasis

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