Abstract
Role of P38 MAPK in Bile Formation and Cholestasis
Highlights
The liver is the largest metabolically active exocrine gland of the body and produces bile that serves as the excretory route for endogenous and exogenous compounds
The aim of this review is to summarize our current understanding of the role of p38 MAPK and its isoforms in bile formation and cholestasis
Acute cholestasis induced by TLC and E-17G is associated with the retrieval of Bile Salt Export Pump (BSEP) and Multidrug Resistance Protein 2 (MRP2) from the canalicular membrane and these effects are reversed by cAMP [23,24,30]
Summary
The liver is the largest metabolically active exocrine gland of the body and produces bile that serves as the excretory route for endogenous and exogenous compounds. Isoforms are likely to be in turn regulated by various PKCs. The effect of p38 MAPK isoforms in bile formation and cholestasis should be taken into consideration when developing p38 MAPK inhibitors for inflammatory diseases to avoid liver toxicity. Acute cholestasis induced by TLC and E-17G is associated with the retrieval of BSEP and MRP2 from the canalicular membrane and these effects are reversed by cAMP [23,24,30].
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