Abstract
Lopez Barnc于1988年采用全细胞膜片钳技术发现了大鼠颈动脉体Ⅰ型细胞膜上对低氧敏感的钾(K+)通道,称为氧敏感K+通道(O2-sensitive K+channels).在肺动脉平滑肌细胞(PASMCs)中亦存在此种离子通道.低氧时PASMCs的K+外向电流发生抑制,膜发生除极化,继而L-型电压门控Ca2+通道开放,Ca2+内流使PASMCs内[Ca2+]升高,平滑肌细胞收缩,最终导致低氧性肺血管收缩(hypoxic pulmonary vasoconstriction,HPV)。
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