Abstract
Osteopontin(OPN) is a secretory, chemokine-like, glycosylated ECM-asseciated protein that interacts with integrins and CD44. OPN plays a crucial role in both physiological and pathological processes in varieties of organs and tissues. Since its first identification in bone, the muhifaceted roles of OPN have been an area of intense investigation. Extensive research suggests the important role of OPN in regulating the cell sig-naling contributes to tumor progression and metastasis. This review focuses on recent advances on functional roles of the OPN-induced signaling pathway in the regulation of cell migration and tumor progression and impli-cations for identifying novel targets for cancer therapy. Key words: Osteopontin; Neoplasms; Signal transduction
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