Abstract
Deep vein thrombosis is a common vascular disorder and association of Homocysteine with DVT is known. Evidence of decrease B12 and folic acid levels in DVT with Hyperhomocysteinemia has also been reported. Scanty data is available regarding role of folate and vitamin B12 on Homocysteine levels in DVT patients. The present study was undertaken in 100 patients. Study group comprised of 50 patients who had clinical features suggestive of DVT and 50 patients, who did not have clinical features suggestive of any venous or arterial disorder, were labelled as control group. All the patients of study group were given vitamin B12 and folic acid treatment along with standard treatment of DVT. Serum Homocysteine, folate, vitamin B12 were measured in all the patients in both the groups and estimated by chemiluminescence technology. After 12 weeks of vitamin B12 and folic acid therapy, serum Homocysteine levels, folic acid levels and vitamin B12 levels of study group were again estimated. The collected records and data was analysed statistically by Student t-test and Chi-square test. Mean Homocysteine level in study group was significantly higher as compared to control group (19.63 ± 19.14 µmol/mL vs. 7.0 ± 4.94 µmol/mL). Mean Homocysteine levels before treatment were 19.63 ± 19.14 µmol/mL and after treatment they were significantly reduced. Hyperhomocysteinemia is a risk factor for deep vein thrombosis. Folic acid and B12 therapy reduced the level of Homocysteine suggesting that this may decrease the chances of recurrence of DVT.
Highlights
Deep Vein Thrombosis (DVT) has an incidence of 5, 00,000 cases per year worldwide [1][2][3]
They concluded that Hyperhomocysteinemia is independently associated with DVT and Homocysteine levels should be assessed in patients with DVT and effect
Falcon et al found higher mean serum Homocysteine levels in patients with DVT to be higher as compared to 8.3 ± 3.4 in control group [16]
Summary
Deep Vein Thrombosis (DVT) has an incidence of 5, 00,000 cases per year worldwide [1][2][3]. Souheil et al in their case control study found that plasma total Homocysteine concentrations were significantly higher in patients with DVT and in patients with idiopathic DVT as compared to controls. They concluded that Hyperhomocysteinemia is independently associated with DVT and Homocysteine levels should be assessed in patients with DVT and effect. Increased Homocysteine level is an independent risk factor for atherosclerosis, venous thromboembolic disorders like DVT and pregnancy related complications [1][14]. Homocysteine levels should be tested in patients with or at risk for blood clots, atherosclerosis or pregnancy complications [15]. The present study was planned to explore the role of folate and vitamin B12 on Homocysteine levels in DVT patients and the possible benefits of folate and vitamin B12 supplementation
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