Abstract
Background Hyperoxia contributes to the development of bronchopulmonary dysplasia (BPD). NrF2-mediated induction of NADPH Quinone oxydoreductase enzyme (NQO1) is known to protect the tissues from hyperoxic injury. Sulforaphane is a potent inducer of NrF2 and NQO1, and has been shown to improve cell survival under hyperoxic conditions. Objective To test the hypothesis that human pulmonary cells carrying specific SNPs on the human Nrf2 and NQO1 genes will display decreased inducibility by sulforaphane. Design/Methods: H441 cells …
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