Role of Notch signaling pathway in the pathogenesis of infantile hemangioma

Abstract

Infantile hemangioma is the most common benign neoplasm in infants. At present, studies are mostly limited to the molecular mechanism of the formation of infantile hemangioma, but the mechanism of its proliferation and regression is still unclear. It is considered that the occurrence of infantile hemangioma is related to abnormal proliferation of vascular endothelial cells and aberrant expression of cytokines, such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) . Recent studies have suggested that Notch signaling pathway plays an important role in the occurrence and development of infantile hemangioma. Notch signals participate in the proliferation and degeneration of infantile hemangioma by stimulating and regulating VEGF and its receptors as well as affecting the proliferation of vascular endothelial cells. Clarifying the role of Notch signaling pathway in the pathogenesis of infantile hemangioma will provide rational treatments of infantile hemangioma. Key words: Hemangioma; Infant; Signal transduction; Vascular endothelial growth factors; Notch signaling