Role of new Antioxidants in the Stabilization of Ophthalmic and ear Dosage form Preparation of Hamycin

Abstract

AbstractThe study involves the development of eye-ointment and ear-drop dosage form of hamycin, a polyene antifungal antibiotic, using anti-oxidants and stabilisers to enhance the stability of these dosage forms. It has been found that incorporation of hydroquinone (HQ), butylated hydroxy anisole (BHA), nordihydroguiaretic acid (NDGA), sodium deoxycholate (DSC) and ascorbyl palmitate (AP) in varying combinations in the dosage preparation have enhanced the stability and preserved physicochemical properties of the ointment for a period of 12 months period under refrigerated temperature (8+2°C) conditions. It was further observed that this dosage preparation is more stable in polyethylene glycol bases than in lanolin bases. Ear-drops dosage preparation has shown stability for 12 months period in the presence of BHA and in combination of other antioxidants under refrigerated temperature. However, ear-drops dosage form was found to be stable only for a period of 6months in ambient condition. It is therefore, r...