Role of Neutrophils on the Ocular Surface.

Yongseok Mun,Jin Sun Hwang,Young Joo Shin

doi:10.3390/ijms221910386

Abstract

The ocular surface is a gateway that contacts the outside and receives stimulation from the outside. The corneal innate immune system is composed of many types of cells, including epithelial cells, fibroblasts, natural killer cells, macrophages, neutrophils, dendritic cells, mast cells, basophils, eosinophils, mucin, and lysozyme. Neutrophil infiltration and degranulation occur on the ocular surface. Degranulation, neutrophil extracellular traps formation, called NETosis, and autophagy in neutrophils are involved in the pathogenesis of ocular surface diseases. It is necessary to understand the role of neutrophils on the ocular surface. Furthermore, there is a need for research on therapeutic agents targeting neutrophils and neutrophil extracellular trap formation for ocular surface diseases.

Highlights

The ocular surface of the eyeball is the part of the eye in contact with the outside world, serving as a primary barrier against external substances and pathogens [1]
Neutrophil extracellular trap formation contributing to autoimmune diseases
Interaction of neutrophil and adaptive immune response including T cells and B cells Neutrophils contribute to allergic response

Summary

Introduction

The ocular surface of the eyeball is the part of the eye in contact with the outside world, serving as a primary barrier against external substances and pathogens [1]. The cornea is a transparent tissue that refracts light entering the eye, focusing it on the retina and acting as a barrier against the outside [2]. The conjunctiva is a mucous membrane that attaches to the cornea and becomes the surface surrounding the eyeball [3]. It forms a conjunctival sac surrounding the inner eyelid and connecting to the eyelid [2]. The ocular surface immune system can be divided into innate and adaptive immune systems [4]. The innate immune system includes basophils, dendritic cells, eosinophils, Langerhans cells, mast cells, monocytes and macrophages, neutrophils, and natural killer cells, whereas the adaptive immune system includes T and B lymphocytes [5]

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Results

Conclusion