Abstract
Objective : to study the level of neurotrophins in serum of patients in the recovery period of ischemic hemisphere stroke before and after treatment with choline alphosceratus. Materials and methods . Complex neuropsychological examination and assessment of neurotrophic factors level by ELISA were carried out in 70 patients after first ischemic stroke. Results . Patients in the recovery period after first ischemic stroke had significant decrease both of neuropsychological status outcomes and the level of nerve growth factor (Nerve Growth Factor – NGF) up to 139,77 ± 43,5 ng/ml. After 3 months of treatment with choline alphosceratus the basic objective outcomes of neurological status and daily activity improved and the level of NGF in the peripheral blood increased up to 1838,93 ± 195,26 (p<0.05). Conclusions . Emotional and cognitive impairments in patients in the recovery period of ischemic stroke are associated with decreased level of NGF in the peripheral blood serum. Choline alphosceratus treatment activates neurotrophic systems of the brain.
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