Abstract
Repeated exposure to social stress results in emergence of psychosocial disorders such as depression and anxiety disorders. Women are at a greater risk of developing stress-related disorders than men, yet the mechanisms regulating this disproportionate risk remain unclear. Utilizing a model of bearing witness to social defeat stress in rats (witness stress, WS) we previously reported that females demonstrate heightened stress sensitivity, and sensitized inflammation was a distinguishing feature in females compared with males.
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