Role of Neurohormonal Modulators in Heart Failure with Relatively Preserved Systolic Function

Abstract

“Cardiovascular disease remains the leading cause of mortality in the developed world. It is estimated that 5 million Americans suffer from heart failure (HF), and roughly 550,000 new cases are diagnosed annually. Studies have found that 40% to 71% of patients who have HF have relatively preserved systolic functions, or diastolic heart failure (DHF). Although there are abundant data to guide the treatment of heart failure and systolic dysfunction, evidence-based data are lacking in the management of DHF. This article examines the role of neurohormonal modulators in the management of DHF.”