Abstract

Background: The role of neoadjuvant chemotherapy (NAC) versus neoadjuvant chemoradiation (NACR) on both downstaging and overall survival has been controversial. The final goal in the treatment of pancreas cancer is downstaging and improvement of overall survival (OS). The newly added variables in the national cancer database (NCDB) in 2018 “post therapy path” provide a unique opportunity to evaluate the role of perioperative treatment on pathologic response and translation of downstaging on OS in a national cohort.

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