Role of Muscle Profile in Alzheimer’s Disease: A 3-Year Longitudinal Study

Abstract

Introduction: Many factors are known to affect the rate of cognitive decline; however, studies on clinical outcomes are rare. Muscle profile and their relationship to dementia trajectories have not been extensively investigated. We investigated factors that affect the rate of clinical decline and the usefulness of muscle profiles for predicting the clinical outcomes of patients with Alzheimer’s dementia (AD). Objective: Sixty-nine subjects with probable AD were included and several factors that are known to affect the rate of cognitive decline were evaluated. Methods: Over a period of 3 years, each subject received an annual evaluation that included a clinical interview and an assessment of their cognitive status as measured by a clinical dementia rating-sum of boxes (CDR-SOB) score. Linear mixed-effects models were used to test for associations between each factor and the ­CDR-SOB score over time. These analyses were repeated in a multivariate linear mixed-effects model after adjusting the covariates. Results: Age, diabetes mellitus, and baseline dementia severity were identified as potential covariates that influence clinical progression. However, a subject’s muscle profile was not found to predict dementia progression. Conclusions: We expect that early screening and intervention, as well as new drugs with mechanisms of action similar to those of antidiabetic medications, will help patients with dementia maintain their clinical status.