Abstract

Introduction: Biliary tract carcinomas are relatively rare, yet the third most common cause of cancer-related death worldwide. Identification of reliable molecular markers may provide valuable prognostic information and facilitate adequate treatment plans and target for a novel therapeutic approach.. Objective:1.to study the distribution of molecular markers among cases and control for predictive value,sensitivity and specificity.2.to study the role of molecular markers in outcome of BTM. Material and methods:Prospective observational study done in radiologically suspected 70 patients in department of surgerybetween 2013 to 2015.Specimen sent for IHC & HPE and the result of molecularmarkers are compared among cases and control..Conclusion and Result:In our study,Muc-1 expression is more specific whereas cyclin D1 expression is more sensitive indicator in differentiating between benign and malignant biliary tract carcinomas, Expression of Muc1 and Muc 4 significantly(p 0.05) .Among these molecular markers expression of Muc-2 significantly affect outcome and its expression is associated with better outcome in patients with Biliary tract malignancy .

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