Abstract

<p indent="0mm">The amino acid sensing system senses amino acid levels both inside and outside the cell and regulates influences protein synthesis and degradation, but also the differentiation and function of the immune cells. The mammalian target of rapamycin (mTOR) and general control nonderepressible 2 (GCN2) are crucial components of amino acid sensing system. In the present study, we briefly show the progression of mTORC1 and GCN2 in amino acid sensing, and then highlight the importance of mTORC1 and GCN2 in immune cell differentiation and function, and their possible roles in immune-related diseases.

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