Abstract
Introduction: Uncontrolled and inadequately managed asthma substantially reduces Quality of Life (QOL) and can lead to premature death. The aim of this study is to understand the role of montelukast in improving quality of life in asthmatic patients by comparing it with placebo.Methods: This prospective, single-arm, interventional study was conducted from September 2019 to February 2020 in the pulmonology outpatient department of a tertiary care hospital in Pakistan. All patients were prescribed montelukast (10 mg once daily).Results: At day 28, participants had a higher score on the Asthma Quality of Life Questionnaire-Standard (AQLQ-S) overall and in all sub-domains compared to day 0. The improvement was significant overall and for the sub-domains of symptoms, activity limitations, and environmental stimuli.Conclusion: Montelukast has an effective role in asthma control as well as in improving the quality of life in the Pakistani population.
Highlights
Uncontrolled and inadequately managed asthma substantially reduces Quality of Life (QOL) and can lead to premature death
At day 28, participants had a higher score on the Asthma Quality of Life Questionnaire-Standard (AQLQ-S) overall and in all sub-domains compared to day 0
The binding of CysLT1 with leukotriene D4 (LTD4) leads to allergic and hypersensitivity reactions, montelukast plays a vital role in the management of asthmatic patients [8]
Summary
Uncontrolled and inadequately managed asthma substantially reduces Quality of Life (QOL) and can lead to premature death. The aim of this study is to understand the role of montelukast in improving quality of life in asthmatic patients by comparing it with placebo. Asthma is quite common worldwide affecting approximately 339 million people, and according to studies, it is estimated to affect 100 million more people by the year 2025 [2]. It is not adequately being managed, leading to low Quality of Life (QOL) and early death. Asthma is rated as the 16th cause of Disability Adjusted Life Years (DALYs). Asthma leads to increased burden of disease, as it ranks 28th among other causes [2]
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